BIO380H5 Lecture Notes - Lecture 14: Neural Development, Immunohistochemistry, Gastrulation
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1) The studies in cell sorting and affinity demonstrated
A | the epidermis has a tighter affinity that the nueraltissue |
B | the mesoderm is never capable of resorting as the outter layerof a re-sorted tissue |
C | all of the above |
D | mesoderm actually requires input from both the ectoderm andendoderm to "know" it's middle location |
E | there is no mechanism in which cells known their properlocation identity within a developing embryo |
2) The extracellular matrix
A | provides a structure for cells to crawl over |
B | contains multiple signaling proteins to guide/repel cells sothey progress in the correct direction |
C | interacts with the transmembrane proteins on the cells toproduce a response |
D | all of the above |
3) EMT is required
A | for mammary glad formation |
B | for progression of cancer from single tumor to metastaticcancerous cells roaming throughout the body |
C | for neural crest cell formation which provides the cells forinternal organs |
D | all of the above |
E | for the initiation of gastrulation in birds and mammals becausethey form as a disc and not a ball of cells |
4) Permissive induction
A | allow for species to change their genetic fate due to thesignals recieved from surrounding tissue |
B | describes regions of specificity hotspots within the developingembryo |
C | describes when cells that no indication towards their fate dueto having the proper signalling/surroundings |
D | none of the above |
5) Classical Cadherins (those dependent on calcium for properfunction)
A | all have the same sequence identity (~98%) on the intracelluarside acroos multipe species |
B | are all regulated by the same 3 catenin proteins to regulatestability and cytoskeletal regulation |
C | Require calcium for a conformational change to present theirbinding site |
D | are very specific to which other cadherin on the neighboringcell it is interested in binding to |
E | all of the above |