BIO202H5 Lecture Notes - Lecture 7: Conformational Change, Depolarization, Resting Potential

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1 Mar 2017
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We are electrically neutral because of the membranes in the body. There are different charges that are separated by a membrane: the membrane separates the charges. The channels are like switches: the charges move. Ohms law: the separation of potential of charges is determined by flow of charges, r = resistance to flow. I = current from one point to another. Channels can be resistors as well as other parts of the membrane. There is resistance in the membrane: how think or how long the membrane is. Cm = capacitance of membrane: how much of the ions is the membrane holding, relatively or proportional to resistance within membrane. The flow depends on the length: longer the cell membrane, the more resistance. Increase in radius can possibly speed up signal. Membrane area and thickness is proportional to capacitance. Membrane can store the ions and slowly leak them out. Ion channel, ion pump and voltage-gated channel all work in maintaining electrical gradient.

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