BIO200H5 Lecture Notes - Lecture 1: Limb Development, Drug Discovery, Ubiquitin
Document Summary
As a review: chirality = handedness (how it looks); specifically, whether it influences light to l or r. it"s chiral if one central carbon atom is attached to. One example is alanine (exists either as l-alanine which rotates to left our body uses this alanine and is recognized by our body. Or there"s d-alanine what you see if you take a mirror image of the l- alanine). When you hold the reflection next to the original, the center will not project in the same direction. Same atoms in central atom, but the atoms direction is pointing differently an anantiomer) Assigning chirality (also review from last lec): find chiral center. If h is towards you, the opposite chirality of what you determined. Note: if 2 atoms have same atomic #, go further out from center until you find a difference. Why is chirality important? (review from lec 1) A chiral drug with 1 chiral center will have an enantiomer.
