BPS 1101 Lecture Notes - Lecture 7: Agostino Bassi, Louis Pasteur, Miasma Theory
16 Jun 2016
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Life expectancy has doubled in last 100 years. Causes of death shifted from infectious diseases to wear and tear. 1900: 44 years, main causes of death. 2004: 82 years, main causes of death. Agostino bassi proved germ theory of disease (1844) Map of cholera infections identified the source infected water pump. Paul ehrlich and the magic bullet deliver pathogens to cure diseases/cancer (1907: trypan red selectively colours trypanosomes, ehrlich knew as was similar to n but more poisonous. Salvarsan 606 to treat syphilis the great pox (developed by ehrlich) Gerhard domagk at ig farben (1932) discovers sulfa. Sulfa drugs mimic natural substrate (drug gets jammed in the enzyme) Mold prevented bacterial growth: used an extract to purify bacteria bacterial artist, fleming did not do the key expirement. Howard florey & ernst chain isolate penicillin (1941: penicillin first produced in milk bottles. 1 000 kg mold gave 1 g penicillin.
