BIO 4115 Lecture Notes - Lecture 9: Nicotine, Cyan, Glycine Receptor
12 Apr 2020
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Christine to (8591008: describe the overall architecture of the human 4 2 nicotinic receptor structure solved by. Subunit stoichiometries: there are two functional subunit stoichiometries, 3 :2 and 2 :3 , 2 :3 has higher a nity for acetylcholine and nicotine by 100 folds, compared to 3 :2 . 2 :3 is the functional subunit described in this paper. 2: the sodium ion (yellow) binds in the transmembrane domain and the nicotine (green) binds in the extracellular domain. Disul de bonds: the 4 2 receptor is part of the cys-loop receptor family, there is one disul de bond in the extracellular domain between. 6 and 7 strands present in all cys-loop receptors: a unique and de ning feature of this 4 2 nicotine receptor is a second disul de bond in the 4 subunits at the top of loop c. 2: describe the location(s) and chemical composition of the agonist binding sites in the human.
