BIO 3303 Lecture Notes - Lecture 3: Treadmilling, Myofibril, Protein Isoform
4 Jul 2016
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Bio3303 lecture 3 &4, text ch 3-4. Microfilament-based mov"t allow cells to chg shape and move from place to place. Like with microtubules, play impt role in transport of vesicles throughout cells. They"re composed of long strings of actin protein. The monomers aka g-actin. when it assembles into filaments aka f-actin. Actin can grow from both ends but its" 6-10x fast on the + side. the growth at one end and loss at the (-) end is called treadmilling. If the (-) end is stabilized with a capping protein the microfilament can lengthen. A cross-linker aka filamin, can link 1+ microfilaments together. the cross-linker fascin links them parallel, creating actin bundles. when cross-linker dystrophin is used, it attaches it to the membrane. The stiff actin fibers can push the cell outward ie: micrvilli extensions. Filapodia - thin fingerlike extensions of cell supported by the actin cytoskeleton. ie: done to make contact with surrounding cells.
