BIO 3302 Lecture Notes - Lecture 10: Anaerobic Respiration, Hemoglobin, Perfusion
2 Nov 2016
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Adjustment of breath frequency and size to meet physiological needs. Central pattern generator in medulla sends output to appropriate muscles. Higher brain centres - brain sends signals to muscles to contract to breathe. Chemoreceptors - detect blood o2 and co2 levels and ph and adjust ventilation to keep these levels at set point. Sensitive to h+ but respond to blood pco2. Protons don"t pass blood brain barrier easily but co2 does bc lipid soluble and reacts with water to form h. Changes in pco2 in blood, result in changes in protein levels in fluid in brain and those changes are detected by chemoreceptors. Respond to pco2, ph falls, pco2 rises, h rises, drives you to breathe. Oxygen levels fall on mt everset, the peripheral chemoreceptors are detecting it not center. Ventilation keyed primarily to o2, but co2 responses present. Thought to be homologous to glomus cells, located on gill arches.
