BIO 1140 Lecture Notes - Lecture 7: Cytoskeleton, Calpain, Phospholipid Scramblase

• School: University of Ottawa
• Department: Biology
• Course: BIO 1140
• Professor: Caroline Petit- Turcotte

Document Summary

Theres different triggers for casuing cell- death there are 2 ways cell death mechanism works cell either grows or can divide or die, cell number must be controlled. 2 key mechanisms triggered by chemical messengers, stress, cell cycle, toxicity, damage, etc. ) Nematode has a number of cells that can be tracked specific number of cells. Can understand a simple model then apply that to a complex model, same cells die in the nematode,. Necrosis: expands and explodes, theres a point where you can reverse the cell death. Theres something that triggers it such excess . By a trigger of being stress or just having excess and then it tells the cells to release the calcium causing it to be toxic inside the membrane. This makes the calpain which makes it go to the lysosomes causing to release all the enzymes letting the lysosome to ingest the cell and then the lysosome will rupture causing damage to cytoskeleton very unorganized.