BIO 1140 Lecture Notes - Lecture 11: Nuclear Membrane, Deoxyribonuclease, Macrophage
8 Oct 2016
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What are the triggers of cell death: chemical messengers (let the cell know it has to die) All reasons for cell death lead to changes in the cell which lead to its demise. Much of the initial work on apoptosis was conducted using a nematode; c. elegans. They quickly reproduce, small, easy to grow, all have the same number of cells. During development, the same 131 cells apoptose every time. Discovery of ced-3 gene that encodes proteins similar to mammalian protease. During necrosis, the cellular content is no longer intact; every nuclease, every enzyme in the cell is now in the extracellular space and can go damage the neighboring cells. Apoptosis = cell, in an organized fashion, packaged and sent for destruction. Necrosis: the calpain-cathepsin pathway: calpain is a calcium-dependent protease; degrades the lysosome"s membranes, leads to proteases (cathepsin) to be released.
