BIO 1140 Lecture Notes - Lecture 1: Integral Membrane Protein, Inositol, Herman Gorter
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30 Oct 2016
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Fluid mosaic model: singer and nicolson 1972, fluid lipid molecules in which proteins are embedded and freely floating. Cell to cell communications recognition and attachment, gap junctions is a passage way between two cells. The average membrane is about 50/50 lipid and protein. The inner mitochondrial matrix is more protein than lipid. Membranes are assemblies of proteins and lipids held together by non-covalent bonds. Proteins are the mosaic component of the model, are mostly free to move around in the lipid bilayer, usually responsible to the functions of the membrane. The lipid bilayer take care of what can go in and what an go out. F. r. a. p, fluorescence recovery after photo bleaching, label molecules with fluorescent dye, laser beam bleaches an area of the cell surface, fluorescent-labels molecules diffuse into bleached area, showing that it is a fluid layer. Phosphoglycerides: serince, choline, ethanolamine, inositol, 16-18 c, one is saturated, the other is unsaturated.
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