BIOL130 Lecture Notes - Lecture 6: Channelopathy, Parietal Cell, Ion Transporter

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Biological membranes all cells plasma membrane encloses contents of entire cell eukaryotic cells membrane-bound organelles (cid:374)u(cid:272)lea(cid:396) (cid:858)e(cid:374)(cid:448)elope(cid:859) double membranes of mitochondria and chloroplasts. Polar head (polar), fatty acids (non-polar: also with steroid (cholesterol) & glycolipid (galactocerebroside) Membrane fluidity how easily lipid molecules move within a membrane leaflet. Tightly packed membrane more viscous, less fluid. Degree of saturation of fatty acids - # of double bonds: typically, one saturated fatty acid and one with one or more double bonds. Fully saturated fas straight packed tightly less fluid. In warm conditions, more cholesterol less fluid. Under physiological conditions, cholesterol makes membrane stiffer less fluid. Cholesterol can make up to 50% of plasma membrane lipid in some animal cells. Transition temp = temp at which membrane gels. At a(cid:374)(cid:455) a(cid:271)o(cid:448)e (cid:858)(cid:396)oo(cid:373) te(cid:373)pe(cid:396)atu(cid:396)e(cid:859) phospholipids i(cid:374) (cid:373)e(cid:373)(cid:271)(cid:396)a(cid:374)e a(cid:396)e fluid, a(cid:374)d (cid:373)o(cid:448)e f(cid:396)eel(cid:455) At (cid:448)e(cid:396)(cid:455) lo(cid:449) te(cid:373)ps, h(cid:455)d(cid:396)opho(cid:271)i(cid:272) tails pa(cid:272)k togethe(cid:396) a(cid:374)d (cid:373)e(cid:373)(cid:271)(cid:396)a(cid:374)e (cid:858)gels(cid:859) (cid:894)solidifies(cid:895) Membrane of a living cell must be able to move (fluid)

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