ZOO 3050 Lecture Notes - Lecture 15: Wnt Signaling Pathway, Dishevelled, Symmetry In Biology
5 Feb 2018
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Review: grey crescent, forms right after fertilization, shift in cytoplasm, bilateral symmetry, where organizer tissue originates, autonomy vs. conditional specification, it is time dependent (before vs. after gastrulation) Uv radiation manipulation will inhibit the cortical rotation (critical for organized function) disrupt the microtubules and so the grey crescent can"t form properly. Ability of goosecoid mrna to induce a new axis. Functions of the organizer: mesoderm specification, differentiates mesoderm, facilitates gastrulation and the movement of these cells, facilitates formation of neural tube (nervous system essential for ns development) Undifferentiated cells show no clear structural features to predict later development: differentiation is a gradual process, cells getting to the right place at the right time and expressing the right genes, committed to cell lineage. Syncytial specification: get interactions between different cytoplasmic regions, do this through specific gradients, after cellular organization these interactions do not occur.
