ZOO 3050 Lecture Notes - Lecture 10: Blastomere, Cell Potency, Blastula

• School: University of Guelph
• Department: Zoology
• Course: ZOO 3050
• Professor: Todd Gillis

Document Summary

Interactions between cells and their environment: soluble signalling factors between cells, cell-extracellular matrix (ecm) contacts: the. Ecm of cells contains secreted proteinsthat activate cellular events in other cells: cell-cell contacts: surface proteins on cells can activate signalling cascades (examples from fertilization) Defect experiment: destruction of one blastomere at 2 cell stage of frog embryo results in development of only one half of embryo, conclusion: autonomous specification (mosaic development) If embryo divided through center of gc two normal embryos develop. Orga(cid:374)izer (cid:894)po(cid:895)(cid:863: tra(cid:374)spla(cid:374)tatio(cid:374) of the po (cid:272)ould i(cid:374)du(cid:272)e (cid:862)(cid:374)ew(cid:863) a(cid:454)es of development, transplantation of po to ventral axis could induce formation of formation of dorsal structures in this region of developing salamander eggs. Isolated animal cap becomes mass of ciliated epidermis. Model for mesodermal induction by vegetal endoderm: ventral signal is released throughout vegetal region, signal induces cells to become mesoderm, dorsal signal from vegetal cells of the nieuwkoop center induces formation of the primary organizer.