ZOO 3050 Lecture Notes - Lecture 16: Neurulation, Paracrine Signalling, Neural Fold
5 Feb 2018
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Cell signalling: transcription factors are doing a form of cell signalling this is not what we will talk about here. Inducer (ligand): typically induced by a tissue, have the capacity to change the cellular fate of the target tissue, responder, tissue whose fate is changing, these are the ones that typically have the receptors. Induction: interaction between inducers and responders, there is auto-induction going on in many cases, problem: positive feedback, tend to have feedback curves that can be over controlled, sometimes the inducer and responder are the same thing. Important to maintain inducer signals for a long enough time. In sea urchins the mouth is fully functional after gastrulation: formation of neural groove, clear separation between endo and ectoderm, ectoderm at end of neurulation is the neural tissue. Liquid is then pumped in (like blowing up a balloon), then you will get the brain. Sort of like an inflation of the area.
