NUTR 3210 Lecture Notes - Lecture 1: Angular Cheilitis, Glutathione Reductase, Pellagra
Document Summary
Know b6 and panthothenic acid formation of coenzyme a. In foods niacin can be bound covalently to other macronutrients. Bound to complex carbohydrates (ef: fibre) = niacytin. Bound to small peptides = niacinogens: niacinogens are the primary form of niacin found in corn. Corn must be chemically treated with bases (eg: lime water) to improve bioavailability of niacin. Pellagra (niacin deficiency) results in populations consuming high corn-based diets that don"t pro(cid:272)ess the (cid:272)orn (cid:449)ith (cid:271)asi(cid:272) solutions. In the liver, nad, and nadp can be synthesized from tryptophan biologically possible but highly inefficient. Inefficient pathway: 1 mg niacin is produced from the ingestion of 60 mg of dietary tryptophan: role of niacin (as nad and nadph) in redox reactions. Nad+ = oxidized nad (dominant pool, 10-fold excess over nadh) mainly due to the activity of the electron transport chain. Nadph = reduced nadp (dominant pool, 10-fold excess over nadp) regenerated/produced by pentose phosphate pathway (hexose monophophast shunt)
