NUTR 3210 Lecture Notes - Lecture 16: Nicotinamide Adenine Dinucleotide Phosphate, Nicotinamide Adenine Dinucleotide, Vitamin B12 Deficiency
20 Apr 2017
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Document Summary
Niacin, thiamin, riboflavin, b6, folate, b12, biotin, pantothenic acid. Niacin converts carbs, proteins, fats to energy. Discovered by studying a condition called pellagra in humans and a similar condition called black tongue in dogs: niacin is the anti-black tongue factor, so, it prevented these diseases, pellagra is a niacin deficiency. High incidence of these conditions (b3 deficiency) in areas where corn is the main dietary staple: this is b/c niacin is bound to complex carbs and poorly absorbed. In animal foods, niacin occurs predominantly as: nicotinamide, nicotinamide adenine dinucleotide (nad, nicotinamide adenine dinucleotide phosphate (nadp) In plant foods, niacin is predominantly found as nicotinic acid (provitamin) Niacin can also be produced in the liver from tryptophan: but only about 1/60th of trp is converted to niacin. Nad and nadp must be digested to absorb niacin: nad and nadp get hydrolyzed in the gut by glycohydrolase to release free nicotinamide.
