BIOL 1090 Lecture Notes - Lecture 17: Protein Folding, Peroxisome, Phospholipid
10 Apr 2018
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Document Summary
Small, spherical, membrane-enclosed organelles that bud off donor compartment and fuse acceptor compartment. Orientation of a protein with respect to the cytoplasm and the interior of membrane-bound compartments is maintained during its travel through the endomembrane system. An inter-connected network of membrane enclosed tubules and flattened sacs. Er membrane is continuous with the outer membrane of the nucleus. In the cytoplasm, ribosomes synthesize polypeptides from mrna -translation. These proteins can be targeted to nucleus mitochondria, peroxisomes, chloroplasts. Translation completed by ribosomes attached to er membrane (rer) Soluble proteins associated with inside of endomembrane system. Ribosomes are targeted to the er membrane by a signal sequence. 1 signal recognition particle binds to signal sequence translation stops. 2 targeting of translation complex to er - srp binds to srp receptor. 4 polypeptide enters the er as it is translated. It is retained in the er, if that is where the protein functions.
