BIOL 1090 Lecture Notes - Lecture 19: Endocytosis, Autophagosome, Defence Mechanisms

• School: University of Guelph
• Department: Biology
• Course: BIOL 1090
• Professor: Andrew Bendall

Document Summary

Amino acid sequence that directs protein back to er = er retrieval signal. Soluble/luminal er proteins contain kdel (lysine-asparic acid-glutamic acid-leucine) retrieval signal. Kdel receptors in membranes of cgn and cis. Golgi bind to retrieval signal of escaped proteins. Kdel receptors bind to copi complex proteins and are incorporated into copi vesicles. Escaped proteins reach the er in (copi coated) Movement of vesicle: uses cytoskeleton and motor proteins. Tethering vesicle to target compartment: uses proteins called rabs. Docking of vesicle to target compartment: uses proteins called snares. Clathrin-coated vesicles move from tgn to other vesicles (ex. lysosomes, endosomes, plant vacuoles: copi-coated vesicles move in retrograde direcion, copii-coated vesicles move in anterograde direcion. Composed of 3 heavy and 3 light chains. Triskelions interact polyhedral laice, a basket like structure that surrounds a vesicle. Ccv adaptor proteins between clathrin laice and the cytosolic face of the vesicle. Selecively sort cargo at tgn, cell membrane and endosomal compartment.