BPK 142 Lecture Notes - Altitude Training, Acclimatization, Cardiac Output

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aquamarinehedgehog675

29 Nov 2011

School

Simon Fraser University

Department

Biomedical Physio & Kines

Course

BPK 142

Professor

Craig Asmundson

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Document Summary

Po2 = partial pressure of oxygen; measures how well your lungs bring oxygen into your bloodstream. Oxyhemoglobin dissociation curve = a mathematical relationship, that is viewed as a graph, showing the amount of oxygen that combines with hemoglobin as a function of the partial pressure of oxygen. Acclimatized = adaptation to a new climate (such as temperature, altitude, etc) Hypoxia = deficiency in the amount of oxygen reaching the tissues. 2,3 dpg = present in rbc; binds with greater affinity to deoxygenated hemoglobin than it does to oxygenated hemoglobin. Medium = 5000 - 10,000 feet = we are concerned with this altitude in relation to athletics. High = >10,000 feet = over 40 million people live/work between 10,000-18,000 feet (3048m 5486m) Barometric (air) pressure decreases when altitude increases. (i. e. , as the weight of the column of air above the point of measurement decreases). The chemical composition is the same up to 20,000m.

Related Questions

1. 2,3-biphosphoglycerate (BPG) regulates high altitude adaptation. The BPG concentration increases from 5 mM at sea level to 8 mM at an altitude of 4500 m in human blood. Please explain how our blood manages to transport enough oxygen at high altitude. If the BPG concentration does not change, how much less oxygen can the blood transport at 4500 m compared to at sea level? (Answer these questions according to the binding curve of hemoglobin for O2 at different BPG concentration). A mutation of hemoglobin reduces the binding affinity of BPG, how will this mutation affect oxygen binding and the oxygen binding curve?

ivorychinchilla895

A mountain climber ascends to an altitude where the partial pressure of oxygen in the atmosphere is very low.

1. What happens to levels of erythropoietin in the blood after a period of time at high elevations?

2.How does a low concentration of oxygen in the alveoli affect the state of contraction of pulmonary arterioles?

3.Explain why pulmonary edema is a symptom of altitude sickness

byzantiumpanda655

Assume that the atmosphere has a temperature (T = 235 K) that isindependent of altitude. The pressure of the atmosphere is the sumof the partial pressures of the gases present (N2, O2, etc.). Thepartial pressure of each type of gas varies with altitude, h,according to the condition of constant chemical potential.

Define h(N2) as the altitude at which the partial pressure ofnitrogen (28 g/mole) falls to 1/2 of its value at sea level. Defineh(H2) as the altitude at which the partial pressure of hydrogen (2g/mole) falls to 1/2 of its value at sea level.

What is the difference between h(H2) and h(N2)?

BPK 142 Lecture Notes - Altitude Training, Acclimatization, Cardiac Output

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