BIOLOGY 1A03 Lecture Notes - Lecture 4: Methionine, Conformational Change, Genetic Screen

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BIOLOGY 1A03 Full Course Notes
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BIOLOGY 1A03 Full Course Notes
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Translation requires many components in the process of translation: cellular components are able to read the genetic message in the messenger rna sequence translate this message into the specific primary amino acid sequence of a protein. Each type of trna molecule is not identical, and as a result can translate a specific mrna codon into a specific amino acid. Anticodon region of the trna, specific nucleotide triplet that forms complementary base-pairs with a specific mrna codon. A(cid:374)ti(cid:272)odo(cid:374)s are (cid:272)o(cid:374)(cid:448)e(cid:374)tio(cid:374)all(cid:455) (cid:449)ritte(cid:374) i(cid:374) the 3"->5" dire(cid:272)tio(cid:374) a(cid:374)d alig(cid:374) properl(cid:455) (cid:449)ith (cid:373)rna (cid:272)odo(cid:374)s i(cid:374) the 5"->3" dire(cid:272)tio(cid:374) Activation of a trna molecule with a specific amino acid is carried out by a family of enzymes called aminoacyl trna synthetases specific to the type of trna and corresponding amino acid that it will bind. Active site of these enzymes recognizes the anticodon end of the trna and the region of the amino acid attachment site. 20 aminoacyl trna synthetases, one for each amino acid.

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