BIOLOGY 1A03 Lecture Notes - Lecture 8: Aminoacyl Trna Synthetase, Aminoacyl-Trna, Transfer Rna

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Alastair Tracey Rosa Da Silva

Document Summary

Unit 1- molecular components contribute to translation. information contained in our genome is encoded in our genes: this genetic info is transcribed from sequences of nucleotides along strands of dna into rna. Initiation of translation requires assembly of various components. Methionine will be located in the peptidyl (or p) site of the of the ribosome. Unlike all of the other incoming charged trna molecules at the start of translation. Each subsequent charged trna enters and binds w/in aminoacyl (or a) site of the large ribosomal subunit. Before each a. a is added to growing polypeptide chain. This is accomplished as the sequence of mrna coding for amino acids is read by the ribosome in successive, non- overlapping groups of three nucleotides. Each incoming charged trna is delivered in association with a gtp-bound elongation factor. Further gtp hydrolysis enables dissociation of the translation complex including ribosomal subunits and any remaining bound trna: prokaryotes& eukaryotes: require same basic machinery during translation.