BIOL 201 Lecture Notes - Lecture 22: Treadmilling, Cdc42, Wild Type
23 Apr 2016
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Fh2 binds to + end and forms dimers. Formin sits on + end and through interactions works with profilin that interacts with fh1 domain and enhances corporation of g actin monomers in the + end. Cells can detect a molecule telling them which direction to move chemotaxis. Stress fibers are important for contractile movements: puts down anchors with integrin proteins. Bind to extracellular matrix and link to bundles in the stress fibres so they can exert force for contractility: contractile motors = myosin, protein that produces force and moves along actin filaments. Use atp to hydrolyze and exert a force. Motor proteins: use atp to do mechanical work. Myosin head carries out conformational change associated with movement on actin network. Myosin heads always direct movement towards the +, led by heads. Myosin class i: step size: 10-14 nm, one single head domain, associated with membrane, endocytosis.
