BIOL 201 Lecture Notes - Lecture 14: Focal Adhesion, Cell Adhesion, Leading Edge
20 Feb 2018
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Contraction: how cells pick up their back feet. Cell migration coordinate force generation with cell adhesion and membrane recycling. Moving fibroblasts display characteristic sequence of events: extension of membrane protrusion. Network of actin filaments at leading edge works similarly to propulsion of. See last lecture: attachment to substratum. After membrane has been extended, actin network assembled, cell membrane attaches to ecm. Actin in leading edge attach to focal adhesions. Attaches cell to ecf to allow movement. Focal adhesion points are involved in signal transduction pathways. External domain binds to specific components of the ecf: ex: fibronectin, collagen. Cytoplasmic domain lings to cytoskeleton: forward flow of cytosol. Bulk content of the cell is translocated forward. Thought to be due to a myosin ii-dependent mechanism which compressed the back of the cell, squeezing the organelles and nucleus forward. Ex: like the contents in the cell are toothpaste getting squeezed forward in the tube.
