PSYC 441 Lecture Notes - Lecture 4: New Approach, Bipolar Disorder
28 Oct 2017
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We can use this fact to look for locations on chromosomes that are associated with a disorder across multiple generations of the same family (i. e. we can look at the whole genome, not just one gene): However, often the families of people with sz look like this (i. e. fewer generations/family gene history make linkage studies more difficult): results of linkage studies, not very conclusive (25 studies with no single gene effect): We look at individuals (as opposed to families): This gives us more power (because we compare many people), but we can only test one gene at a time (which takes a while and is only based on guesses): This problem can be solved with genome-wide association. 15): many studies that have been replicated implicate genes involved in gaba regulation and the immune system: Basically, there are many avenues to research: gwas, a multi-center study with 200 cases and 13, 500 controls found: Four potential locations (2 on chromosome 6).
