BIO230H1 Chapter Notes -Intermediate Filament, Protein Filament, Spindle Apparatus

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13 Mar 2014
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BIO230H1 Full Course Notes
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BIO230H1 Full Course Notes
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The cytoskeleton: cytoskeleton: system of protein filaments in the cytoplasm of a eukaryotic cell that gives the cell shape and the capacity for directed movement. The self-assembly and dynamic structure of cytoskeletal filaments: most animal cells have 3 cytoskeletal filaments that are responsible for the cells" spatial organization and mechanical properties: intermediate filaments, microtubules, and actin. Microtubules determine the positions of membrane-enclosed organelles and direct intracellular transport. Actin filaments determine the shape of the cell"s surface and are necessary for whole-cell locomotion: they would be ineffective without accessory proteins. Individual macromolecular components are in a constant state of flux: microtubules typically near nucleus. They can typically rearrange themselves to form a bipolar mitotic spindle during cell division. Can also form cilia and flagella: actin filaments underlie the plasma membrane of animal cells, providing strength. Actin is the contractile ring that splits cells in 2.

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