BIO230H1 Lecture 14: Part 2-Lecture 2 (Ch.16)

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BIO230H1 Full Course Notes
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Spatial and mechanical functions of cells depend on system of filaments the cytoskeleton. Varied functions depend on behaviour of 3 families of protein filaments: actin filaments, microtubules and intermediate filaments. Actin filaments determine shape of cell"s surface and are needed for whole-cell locomotion: drive pinching of one cell into two. Microtubules determine positions of membrane-enclosed organelles, direct intracellular transport and from mitotic spindle during cell division. Accessory proteins needed for controlled assembly of cytoskeletal filaments in certain locations: include motor proteins convert energy of atp hydrolysis into mechanical force to move organelles along filaments/move filaments themselves. Cytoskeletal filaments adapt to form dynamic or stable structures. Structural rearrangement in a cell requires extra energy when conditions change. Actin filaments: underlie plasma membrane of animal cells, provide strength and shape to bilayer, form many cell-surface projections. Lamellipodia and filopodia used to explore territory and move around.

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