NURS 165 Study Guide - Final Guide: Reuptake, Tricyclic Antidepressant, Carbamazepine
Drug
Indication
Mechanism
Duration
Elimination
Side Effects
Adverse
RXNs
Interactions
Morphin
e
severe pain
(acute or
chronic)
μ-opioid-
receptor
agonist
~4-6h (PO,
IV), 12-
24h
(epidural)
hepatic
metabolism;
glucuronic acid
active
metabolites are
excreted renally
sedation, miosis, nausea,
vomiting, constipation,
hypotension, urinary
retention, cough
suppression, respiratory
depression
pruritus
anticholinergics, opioid
antagonists, CNS depressants
Fentanyl
severe pain
(acute or
chronic)
μ-opioid-
receptor
agonist
</=1h (IV),
48-72h
(transder
mal)
hepatic
sedation, miosis,
vomiting, constipation,
urinary retention, cough
suppression, respiratory
depression
pruritus
anticholinergics, opiod
antagonists, CNS depressants
Naloxone
opioid
reversal
μ-opioid-
receptor
antagonist
~1h (IV),
longer
(SC)
hepatic (t1/2
~1-2h)
hypergalsia, withdrawal
syndrome, seizure, CV
instability
opioid agonists
Aspirin
pain
associated
with
inflammatio
n
inhibits
cyclo-
oxygenase
COX
(Cox1>COX2)
650mg
q6h
hepatic, then
renal
GI distress (including
bleeding), tinnitus,
altered hemostasis, renal
dysfunction
hypersensiti
vity
reactions
(including
anaphylaxis)
aminoglycosides, loop diuretics,
antacids, corticosteroids, other
NSAIDs, anticoagulants
Ibuprofe
n
pain
associated
with
inflammatio
n
inhibits COX
within 60
min/ 4-6
hrs
hepatic, then
renal
GI distress (including
bleeding), tinnitus,
peripheral edema, renal
dysfunction
hypersensiti
vity
reactions,
SJS
ACE-inhibitors, diuretics,
antacids, anticoagulants
Acetamin
ophen
mild to
moderate
pain, fever
inhibits
prostaglandi
n synthesis
~15min/
~4h
hepatic
nausea, vomiting
leukopenia,
hepatic
dysfunction
antacids, ethanol
Tramadol
mild-
moderate
pain
spinal
inhibition of
NE, 5HT
(serotonin)
reuptake;
~1h/6-8hr
hepatic
metabolism
(CYP2D6/3A4),
renal excretion
(~30%
sedation, dizziness, dry
mouth, nausea,
constipation, respiratory
depression, seizure risk
hypersensiti
vity
reactions
CNS depressants, carbamazepine,
quinidine, MAO-inhibitors,
serotonin-reuptake inhibitors
(SSRIs), tricyclic antidepressants
(TCAs)
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Document Summary
Opioid- receptor agonist hepatic metabolism; glucuronic acid active metabolites are excreted renally hepatic. 48-72h (transder mal) sedation, miosis, nausea, vomiting, constipation, hypotension, urinary retention, cough suppression, respiratory depression sedation, miosis, vomiting, constipation, urinary retention, cough suppression, respiratory depression hypergalsia, withdrawal syndrome, seizure, cv instability. Gi distress (including bleeding), tinnitus, altered hemostasis, renal dysfunction. Gi distress (including bleeding), tinnitus, peripheral edema, renal dysfunction. Interactions anticholinergics, opioid antagonists, cns depressants pruritus anticholinergics, opiod antagonists, cns depressants opioid agonists hypersensiti vity reactions (including anaphylaxis) hypersensiti vity reactions, Sjs leukopenia, hepatic dysfunction hypersensiti vity reactions aminoglycosides, loop diuretics, antacids, corticosteroids, other. Cns depressants, carbamazepine, quinidine, mao-inhibitors, serotonin-reuptake inhibitors (ssris), tricyclic antidepressants (tcas) Cox (cox1>cox2) inhibits cox within 60 min/ 4-6 hrs hepatic (t1/2. Acetamin ophen pain associated with inflammatio n pain associated with inflammatio n mild to moderate pain, fever. Tramadol mild- moderate pain inhibits prostaglandi n synthesis spinal inhibition of.
