PHA 3112 Study Guide - Final Guide: Opioid Antagonist, Opioid Overdose, Orthostatic Hypotension

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: Pierre Fortier

Document Summary

Drug list 5: ch 28 opioid analgesics/antagonists: buprenorphine (butrans, others) Pharmacologic actions: opioid agonist-antagonist; agonist at mu receptor & antagonist at kappa receptor. Have greater abuse potential than other agonist-antagonist. Use: managing opiate agonist withdrawal: morphine [ms contin, others] Source; extraction from opium from poppy plant. Effects: produce analgesia, euphoria, sedation, respiratory depression, physical. Therapeutic use: relief for pain: moderate to severe pain: postoperative cancer, labor & delivery. Relieves pain without affecting other senses & without causing a loss of sonciousness. Dosage depe(cid:374)ds o(cid:374) the pt"s pai(cid:374) le(cid:448)el. Pharmacokinetics: oral doses must be large to achieve same analgesic effect. Precautions: avoid use in pregnancy, labour & delivery, head injury and decrease respiratory reserve. Drug interactions: don"t combine with meperidine with monoamine oxidase (mao) inhibitor. Cause excitation, delirium, hyperpyrexia, convulsions and severe respiratory depression and death. Toxicity: opioid overdose: triad of symptoms: coma, respiratory depression, pinpoint pupil, and death. Wd symptoms: yawning, rhinorrhea, sweating, followed by anorexia, irritability, tremor & gooseflesh.