NURS 165 Study Guide - Final Guide: Headache, Postganglionic Nerve Fibers, Verapamil
Hypertension
1
Drug
Indication
Mechanism
Onset
t1/2
Excretion
Adverse Effects
Caution
Interactions
Furosemide
volume
overload,
edema
Loop diuretic
IV: .5-1h
PO: 5min
IV:6-8h
PO: 2h
renal,
some
hepatic
volume depletion,
hypotension,
hypomagnesemia,
hypocalcemia,
hyperglycemia, ototoxicity
pregnancy
antihypertensives, Digoxin,
NSAIDs, lithium,
aminoglycoside antibiotics
Hydrochlor
othiazide
HTN, mild
edema
Thiazide diuretic
2h
6-12h
renal
volume depletion,
hypotension, hypokalemia,
hyomagnesemia,
hypercalcemia,
hyperglycemia,
hyperlidpidemia,
hyperuricemia
pregnancy
/ lactation
antihypertensives, digoxin,
NSAIDs, lithium
Spironolact
one
HTN,
edema
K-sparing diuretic
24-48h
48-72h
renal
hyperkalemia, endocrine
effects
other diuretics, ACE-
inibitors, K supplements
Lisinopril
HTN, HF,
MI,
nephropat
hy
ACEI: reduces angiotesin
II, elevates bradykinin
NOT a
prodrug
renal
hypotension, hyperkalemia,
cough, angioedema,
dysgeusia, rash
DONT USE:
pregnancy,
bilateral
renal
stenosis
diuretics or other
antihypertensives, K
supplements
Losartan
HTN, HF,
nephropat
hy
ARBs/ AIIAs: blocks
type1 angiotensin II
receptor
renal
hypotension, hyperkalemia,
angioedema, dysgeusia, rash
DONT USE:
pregnancy,
bilateral
renal
setenosis
diuretics or other
antihypertensives, K
supplements
Aliskiren
HTN
Renin antagonist:
inhibits conversion of
angiotensinogen to angI
biliary,
renal
angioedema, hyperkalemia,
GI effects
furosemide and irbesartan,
CYP3A4 inhibitors
Eplerenone
HTN, HF
K-sparing diuretic/
Aldosterone antagonist
(selective)
hepatic
(CYP3A4),
urine>
intestinal
hyperkalemia, GI effects,
endocrine effects
other diuretics, ACE-
inhibitors, K supplements,
CYP3A4 inhibitors
Prazosin
HTN-
dilates
arterioles
and veins
anti-adrenergic (direct
alpha1 antagonist)
orthostatic hypotension,
reflex tachycardia, inhibition
of ejaculation, nasal
congestion
Metoprolol
HTN,
angina, MI,
HF
anti-adrenergic (direct,
selective Beta 1
antagonist)
hepatic
metb,
renal
bradycardia, AV heart block,
HF, rebound cardiac
excitation, heart block
heart
block
other antihypertensives
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Renin antagonist: inhibits conversion of angiotensinogen to angi. Aldosterone antagonist (selective) anti-adrenergic (direct alpha1 antagonist) anti-adrenergic (direct, selective beta 1 antagonist) Adverse effects volume depletion, hypotension, hypomagnesemia, hypocalcemia, hyperglycemia, ototoxicity volume depletion, hypotension, hypokalemia, hyomagnesemia, hypercalcemia, hyperglycemia, hyperlidpidemia, hyperuricemia hyperkalemia, endocrine effects hypotension, hyperkalemia, cough, angioedema, dysgeusia, rash renal hypotension, hyperkalemia, angioedema, dysgeusia, rash biliary, renal angioedema, hyperkalemia, Gi effects hepatic (cyp3a4), urine> intestinal hepatic metb, renal hyperkalemia, gi effects, endocrine effects orthostatic hypotension, reflex tachycardia, inhibition of ejaculation, nasal congestion bradycardia, av heart block, Dont use: pregnancy, bilateral renal setenosis other diuretics, ace- inibitors, k supplements diuretics or other antihypertensives, k supplements diuretics or other antihypertensives, k supplements furosemide and irbesartan, Cyp3a4 inhibitors other diuretics, ace- inhibitors, k supplements, ~5h other vasodilator (increases cgmp, endothelium release nitric oxide) 6hrs peripheral edema, reflex tachycardia, dizziness, headache, flushing extensive. 1st pass effect, hepatic acetylation orthostatic hypotension, constipation, peripheral edema, dizziness, headache, flushing, av block reflex tachycardia, sle pregnancy other antihypertensives.
