PSIO 532 Study Guide - Final Guide: Zymogen, Trypsin, Enteropeptidase
Graduate Physiology – GI Tract
Small Intestine – Pancreas: Secretion of Enzymes
The exocrine cells in the pancreas play a central role in
the production of digestive enzymes
On the pancreas, the acinar cells are at the end the
enzymes secrete into the lumen space and get released
through the ducts into the duodenum
Gallbladder releases bile; if a gallbladder stone occurs on
the bile duct, it can lead to severe pancreatitis this is
because there would be an accumulation of the enzymes
in the duct or acinar cell lumen;
The main enzymes are made in the exocrine pancreas
the exocrine cells in the pancreas play a central role in
the production of digestive enzymes
Acinar Cells produce and secrete digestive enzymes (there are receptors for certain
hormones and neurotransmitters to regulate their release)
Ductal Cells mainly secretes the fluid bicarbonate
Stomach secretes acid, but eventually you have to neutralize that acid in the duodenum
so your enzymes can be in the optimal conditions to digest food (most of the enzymes
are active in the alkaline pH); the only enzyme active in low pH is pepsinogen/pepsin
Liver secretes bile (it has bicarbonate properties – alkaline) and small intestine secretes
some bicarbonate too all contribute to the alkanization of the contents in the
duodenum
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Document Summary
The exocrine cells in the pancreas play a central role in the production of digestive enzymes. On the pancreas, the acinar cells are at the end the enzymes secrete into the lumen space and get released through the ducts into the duodenum. Gallbladder releases bile; if a gallbladder stone occurs on the bile duct, it can lead to severe pancreatitis this is because there would be an accumulation of the enzymes in the duct or acinar cell lumen; The main enzymes are made in the exocrine pancreas the exocrine cells in the pancreas play a central role in the production of digestive enzymes. Acinar cells produce and secrete digestive enzymes (there are receptors for certain hormones and neurotransmitters to regulate their release) Ductal cells mainly secretes the fluid bicarbonate. Liver secretes bile (it has bicarbonate properties alkaline) and small intestine secretes some bicarbonate too all contribute to the alkanization of the contents in the duodenum.
