BIOL 3090 : Final Unit 3 Review
Document Summary
Swi5 recruits swi/snf (chromosme remodeling complex) ---opens up the chromatin-- >hats come in acylytate the histone core, further open promoter proximal region, another activator sbf binds ppr---> a mediator binds sbf, and a transcription factor binds the mediator which brings this tf to the promotor allowing transcription. Nuclear receptors are a family of tf that respond to lipid soluble hormones that cross the membrane, they have 3 functional regions, dna binding (cterminal), hormon binding domain (c- terminal), and hormon dependent activator domiain (n terminal). They bind hormones, move to nucleus and activate transcription. Can act as hats or hdac depending on whether they have a ligand or not, Heterodimeric nuclear recepros, found in nucleus only, when bound to dna could be acting as repressors (if not bound with ligand) by being a hdat. or an activator (if bound by ligand, by becoming a hat.
