Pharmacology 2060A/B Study Guide - Hydrophile, Asthma, Bioavailability

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 2060A/B
• Professor: Brad Urquhart

Document Summary

2. 2 factors affecting absorption: rate of dissolution, surface area, blood flow, lipid solubility, ph partitioning, activity of drug transport proteins, rate of dissolution. The example to the right shows drugs placed in a liquid. Over time dissolution occurs and the drug molecules are dissolved in the liquid. Surface area is a major determinant of drug absorption. The larger the surface area, the faster drug absorption is. Drugs with high lipid solubility (i. e. lipophilic drugs) are absorbed more rapidly than water soluble (i. e. hydrophilic) drugs. Lipophilic drugs are able to cross the cell membrane whereas hydrophilic drugs can"t: ph partitioning. Drug absorption is greater when there"s a difference between the ph at the site of administration and the blood such that the drug is ionized in the blood. Remember the effect of ph dependent ionization from. The rate and extent of drug absorption can be significantly impacted by drug transporters. Uptake drug transporters increase the absorption of drugs.