BIOL 1101 Study Guide - Midterm Guide: Metastasis, Sister Chromatids, Trisomy

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C6h12o6 + 6o2 6co2 + 6h2o + energy (as atp) Nad+ (main electron carrier) gets reduced to nadh using dehydrogenase. Transport protein, then: dehydrogenation, decarboxylation (before the cycle) 2x (1 acetyl group, 1 nadh, 1 co2) Enters metabolic cycle (citric acid cycle) to be oxidized completely to carbon dioxide. 2x (2co2, 1 atp, 3 nadh, 1 fadh2) Electron transport chain (chemiosmosis inner mitochondrial membrane/matrix) Proton gradient is created using proton pumps (complexes i, iii and iv) The pumps cycle between reduced and oxidized states. Electrons are transferred to water (delivered to oxygen, to form water) Uncouplers unlink the electron transport chain and atp synthase (can be toxic) Page 129 (total atp yield by cellular respiration) More than 30% efficient (32%) rest is heat. Fermentation (lactate or alcoholic [co2 is released]) Pyruvate is reduced converting nadh back to nad+ (allows glycolysis to continue) Ros reactive oxygen species (superoxide, hydrogen peroxide and hydroxyl radical)

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