PHA 3112 Study Guide - Midterm Guide: Unstable Angina, Hydralazine, Verapamil

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: Pierre Fortier

Document Summary

Others: (cid:862)(cid:374)itrates(cid:863), isosorbide (subling. , topical, oral, iv) (cid:862)olols(cid:863) Inhibits angiotensin ii (decreases aldosterone): decreased sodium and water retention, vasodilation. Direct renin inhibitor (inhibits conversion to angiotensin i): decreased sodium and water retention, vasodilation. Inhibits influx of calcium into myocardium and vasculature (relaxation and vasodilation): decreased cardiac output and heart rate. Alpha: prevent stimulation of alpha one receptors on arteries: vasodilation. Act in cns to reduce adrenergic tone: decreases epinephrine + norepinephrine. Vasodilation (reduces preload and afterload), reverses coronary vasospasm. Decrease cardiac contractility, decrease renin release (decreased vasoconstriction and. Methyldopa does not cross placenta: use in pregnancy. Log attacks, no relief go to emerg. Beta and nitrates decreases heart rate and preload. Beta and calcium (cid:271)lo(cid:272)kers do(cid:374)"t use together: too similar. Clopidogrel (alternative to those who (cid:272)a(cid:374)"t handle asa) Heparin (rapid acting injection use with aspirin in unstable angina stop thrombus development, decrease mi), iv, Ex: enoxaparin (sc 1-2 times daily instead of continuous iv) sodium+water retention)