BIOM 4030 Study Guide - Midterm Guide: Anterior Pituitary, Insulin-Like Growth Factor 2, Insulin-Like Growth Factor 1

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 4030
• Professor: Pawel Bartlewski

Document Summary

Paraventricular nucleus of hypothalamus release ghrh/somatostatin (peptides) Acts on gh cells (somatotropes) in anterior pituitary via g protein receptors. Gh (protein) stimulates muscle/bone growth via cytokine receptors. Igf-1 has negative feedback on gh release from pituitary (tyrosine kinase receptors) Several large pulses of release throughout day, largest 1h after sleep. Amplitude and frequency of peaks greatest during puberty then decline. Most transported bound to gh binding protein (ghbp), but some free. Ghbp coded by same gene as gh receptor. Binding protein has same affinity for receptor as gh. May be an evolutionary mechanism to slow distribution of gh. Only hormone that can stimulate tissue renewal. Low neonatally and later in life, high during puberty. Required for skeletal, extra-skeletal development & adipose differentiation. One of first hormones to appear in fetal pituitary gland, but does not regulate growth until after birth. Gh and igf-2 grow long bones in children.