BIOM 3200 Lecture Notes - Lecture 4: Anterior Pituitary, Paraventricular Nucleus Of Hypothalamus, Somatomedin
10 Feb 2018
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Ghrh gh (somatotropin) igf-1,2 (somatomedins) (insulin like growth factors) cartilage (affects bone and cartilage) Gh: transport in blood: gh may be transported as free hormone but much of gh is bound to binding protein (ghbp) Regulators of gh secretion: gh acts on the liver to produce igfs, polypeptides with 40% homology to insulin. Igf-1 is almost entirely bound to transport proteins (igf-bp"s: some igf-1 transport/binding proteins have an endocrine function (i. e. , there are receptors for these proteins). Gh plays an especially important role in endocrine regulation of growth (muscle and bone) How do children grow: children have 2 periods of rapid growth: postnatal and puberty, change in proportion (babies and adults have different proportions, will children grow naturally without gh, gh (somatotropin) is made in the anterior pituitary. It is released throughout life, though it"s (cid:271)iggest role is in (cid:272)hildren, and peaks during teenage years.
