NURS 2550H Study Guide - Final Guide: Low-Density Lipoprotein, Homocysteine, Cellular Differentiation
6 Dec 2013
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Principles of drug action: drug interacts with receptor -> bind to receptor -> response, drug alters physiological response, drug always has more than one effect. Drugs bind to receptors instead of natural ligand: mimic neurotransmitter, trick the body into allowing the drug to bind. D (drug) + r (receptor) d r complex response. Receptor function is normally regulated by molecules supplied by the body. A drug cannot make the body do something new, only help the body to help itself. Span cell membrane: cell membrane-embedded enzymes, ligand-gated ion channels, g protein-coupled receptor systems (ex. Ne, serotonin, histamine); binding of endogenous ligand or antagonistic drug activates receptors -> g protein -> effector: transcription factors (ex. Very slow acting, delayed response (hrs -> days) If a drug interacts with one type of receptor and that receptor type regulates only a few processes, the effects of the drug are relatively selective.
