MICR 360 Study Guide - Final Guide: Envelope Glycoprotein Gp120, P53, Immunodeficiency

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

Which t-cell population: barrier integrity, allergy responses c, kills virus-infected. Supress t-cells cells: activates macrophages, ab production. Where do viruses and bacterium go in cells: cd4 th17 cells: enhance neutrophil response promotes barrier integrity (skin, intestine); inflammatory, helps produce cytokine il17, cd4 th2 cells: helps b-cells for antibody production, especially switching to. Cd4 regulatory t-cell: wants to fight but treg supresses immunity! Mycobacterium, tuberculosis, mycobacterium leprae, leishmania donovani, pneumocystis carinii. Antigen uptake by langerhans" cells (immature dc) and migration to nodes. In the epidermis: to phagocytose bacteria migrates through skin to lymph vessels in the dermis. Enter the lymph node from infected tissue, can transfer some antigen to resident dendritic cells b7-positive dendritic cells stimulate naive t-cells. Differentiation into mature dendritic cells w/ co-stimulatory activity to activate na ve t-cells (can now make cytokines & can activate t-cells!) Apcs (3 signals): ag-specific signal: activation, b7/cd28: survival/costimulation (b7, cytokines: differentiation (ie. il-6, il-12, tgf- , il-4 produced depending on infection)