MICR 360 Study Guide - Midterm Guide: Xenotransplantation, Immunogenicity, Urushiol
23 Dec 2018
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Ag: molecules that can be degraded into peptides + rec by t cells or can react w specific ab, not always immunogenic. Epitope: portion of ag bound by ab or tcr, can be linear or discont epitope that is rec by b cells. Valency: # of epitopes on an ag, typically ags are multivalent, monomeric ab always has a valency of 2. Immunodominance: comparative immunogenicity of an epitope from an ag, 1 ag induces more pronounced response than others. Ab binds ag w noncovalent interactions (electrostatic, h bonds, van der waals, hydrophobic) thru lock and key fit. Foreignness + size prop to immune response, isogenic (self) synergistic (twin) allogeneic (diff indiv) xenogeneic (diff species), large + xenogeneic= most immunogenic. Hapten: organic molecule that is immunogenic only when attached to larger protein ex. urushiol. Adjuvants: enhance immunogenicity when injected w ag ex. vaccine for hep b. Route of exposure: influences which immune organ + cell pop is involved.
