HTHSCI 2C06 Study Guide - Final Guide: Inflammatory Myopathy, Systemic Lupus Erythematosus, Hypotension
20 Apr 2016
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Increase blood levels of nitrogenous wastes and impair fluid and electrolyte balance. Nsaids inhibit prostaglandin synthesis (prostaglandins are vasodilators: indicated by a sharp decrease in urine output and an elevation in bun in relation to serum creatinine levels. Seepage of intracellular proteins, electrolytes and myoglobin into the systemic circulation. Leads to renal failure in severe cases. Causes: extreme exertion, environmental heat illness, sickle cell trait, seizures, hyperkinetic states, ect, metabolic myopathies, mitochondrial myopathies, malignant hyperthermia, neuroleptic malignant syndrome. Infections: alcoholism, venom, co, fibrates, statins, phenytoin, hiv, malaria, toxic shock. Genetic defects: vasculitis, polymyositis, disorders of lipid metabolism/glycolysis/mitochondrial. Lab values reaching 3 million iu/l: creatine kinase (ck)= 23,000 u/l elevations of this enzyme, with extreme cases, ast= 1,030 u/l, and alt=393 u/l, creatinine= 255 umol/l. A transient elevation in serum creatinine disproportionate to the: serum uric acid may exceed 40mg/dl. (hyperuricemia, hypoalbuminemia, hyperkalemia, myoglobinuria elevation of bun is common in early acute stage.
