PSYC 318 Study Guide - Midterm Guide: Melanocortin 4 Receptor, Proopiomelanocortin, Gaba Receptor
15 Jun 2016
School
Department
Course
Professor
Document Summary
Weight loss lowers leptin and insulin signal, reduce sensitivity to ckk, reduced sensation of satiety (harder to feel full) Agrp neurons orexigenic, promotes hunger inhibited by leptin and insulin, activated by ghrelin release agrp peptide, gaba and npy. Agrp peptide is an inverse agonist of mc4r receptor (long-term effect) Npy and gaba release rapidly stimulate feeding. Pomc neurons anorexigenic, inhibits hunger activated by leptin, inhibited by ghrelin and agrp. Pomc neurons release a-msh peptide, which activates mc4r melanocortin receptors in pvn and reduces hunger. Pvn neurons need to be activated for you not to feel hunger. Agrp neurons inhibit pvn neurons (such that you feel hungry) Pomc neurons activate them (such that you feel full) When fire, reduce food intake get input from cck, leptin and pvn need serotonin input to completely shut off feeding. Parabrachial nucleus (pbn) excess serotonin causes excess nts firing, which will cause excess pbn firing, which causes excess firing in amygdala, and hunger stops.
