BIOM30001 Lecture Notes - Lecture 8: Peptide Yy, Sleep Deprivation, Mesolimbic Pathway

• School: University of Melbourne
• Department: Biomedicine
• Course: BIOM30001
• Professor: All

Document Summary

Hypothalamus is major site for control of appetite and energy expenditure. Hypothalamus receives information from the periphery and other brain region about energy status. Defence of the set-point makes it difficult to maintain weight loss. The risk of an obesogenic environment has contributed to the increase in obesity and overweight. Mesolimbic da system is important for reward (hedonic) obtained from food. Regulation of body weight: energy intake, energy expenditure. Adiposity signal long-term: leptin, released by white adipose, maintain body weight, pass bbb via saturated process. Lack of leptin causes infertile: receptor in hypothalamus, plasma lv proportional to bmi and fat, obesity is a state of leptin resistance. Insulin: hypothalamus, main region to control appetite and energy expenditure. Satiety signal short-term: cck, released by stomach, binds to receptor on vagal nerve to medulla to hypothalamus. Leptin signals in arc (arcuate nucleus) in third ventricle.