PHSI2006 Study Guide - Midterm Guide: Bohr Effect, Cyanosis, Hemoglobin
14 Jan 2019
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Transport of o2 in blood: some is dissolved: 1/5% at normal atmospheric pressure, most combined with hemoglobin- 98. 5, each gram of hb binds 1. 34 ml o2, each 100 ml blood has 15g hb. Blood is nearly fully oxygenated even if po2<100mmhg. Hemoglobin gives up a large volume of o2 for a small drop in po2 at tissues. Plots the proportion of hemoglobin in its saturated form against the proportion of oxygen in the blood (po2) O2 affinity for hb is decreased (shit of o2-hb curve to the right which means easier unloading of o2) if: increased pco2, increased temperature, increased 2,3 diphosphoglycerate, decreased ph acidosis. Bohr effect: the oxygen carrying capacity of hb at a particular po2 is decreased by increased pco2 (wants to counter the huge amount of co2) = easier unloading of o2 in tissues, easier loading of o2 in lungs. Odourless, colourless, non-irritant, no cyanosis: 2. combines with hb at o2 binding site, 3.
