KINE 3012 Study Guide - Quiz Guide: Point Mutation, Potassium Ferricyanide, Pulse Oximetry
2 Sep 2016
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Respiratory process: ventilation (bulk flow), diffusion (alveoli & blood in pulmonary arteries), transport (bulk flow), diffusion (blood in systemic circulation. & the tissues), cellular respiration (o2 utilization, co2 production) O2 is carried in the blood in 2 forms: dissolved in blood. Volume of o2 dissolved in the plasma is directly proportional to the partial pressure of o2 (po2) in the blood. Higher po2, greater the amount of o2 that can be dissolved. At normal arterial po2 of 100mmhg = 3ml o2/l blood which is grossly inadequate: chemically bound to hemoglobin (hb) More than 98% of the o2 in the blood is carried in this manner. Hb is an iron-bearing protein molecule located within red blood cells (erythrocytes). Hb molecule is a tetramer of 2 alpha & 2 beta polypeptide chains (globin subunits); each subunit is associated with an iron-containing heme group. Heme is the pigment that makes blood red. Iron portion of the heme groups interact with o2.
