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What is the SNARE hypothesis in membrane trafficking and how would you test it? I am looking for a complete series of experiments, in vitro and in cells, that would rigorously test the hypothesis.What is the SNARE hypothesis in membrane trafficking and how would you test it? I am looking for a complete series of experiments, in vitro and in cells, that would rigorously test the hypothesis.

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Related questions

Answer the Following A-F

A.What would a cell lacking functional t-SNAREs look like?

B.What are the facilitating roles of SNARE proteins?

C.What is the specific role of NSF and SNAP in vesicle trafficking?

D.During the process of vesicle fusion to target membrane, where is ATP hydrolysis required?

E.What are common features of lysosomal hydrolases?

F.What is the function of cytoplasmic Hsc70 during endocytosis?

Please Help Answer These! I dont understand and my test is tomorrow! Thank You!!!

There had been a long-standing controversy between two different hypotheses about the trafficking of proteins through the Golgi that was resolved in a set of experiments that you studied this semester.

A)(1pt) What were the two hypotheses?

B)(1pt) Briefly describe the critical experiments that solved this controversy making clear which hypothesis was confirmed.

C)(1pt) What experimental evidence would have confirmed the other hypothesis?

D) (1 pt) Given that the experiments you studied were done in unicellular yeast, which hypothesis would you favor for mammalian cells? (note: the genes involved in transport and modification are so strongly conserved between yeast and mammals that the mammalian genes work in yeast)

1/What is the fate of a protein with no N-terminus Signal Sequence?

(a)Transport through the constitutive secretory pathway

(b)Dispersal throughout the cytoplasm

(c)Transport into the nucleus

(d)Transport to the rough endoplasmic reticulum (RER)

2/ In nerve cells, Botulinum toxin-A degrades a subunit of a T-snare localized on the plasma membrane, how would this affect vesicular trafficking?

(a) It blocks the co-translational import of neurotransmitter proteins into the Endoplasmic reticulum via the translocon.

(b) It prevents the addition of carbohydrates to translated proteins

(c)It blocks the fusion of neurotransmitter-containing vesicles with the plasma membrane because theT-snare would not be able tophysically interact with the V-snare.

(d) None of the above

3/

What is the correct order of events of Clathrin-mediated endocytosis?

1. Uncoating of Clathrin- coated vesicle

2. Recruitment of Clathrin and selection of cargo

3. Fusion of vesicle with early endosome

(a) 1, 2, 3

(b) 2, 1, 3

(c) 2, 3, 1

(d) 3, 1, 2

4/ Vesicles traveling anterogradely will eventually fuse with the cell membrane.

Which of the following elements does NOT participate in the fusion event?

(a) v-snare

(b) t-snare

(c) SNARE complex

(d) clathrin coat protein

5/

When a cell releases a hormone into the bloodstream and a number of cells in a

distal location respond, this type of signaling is...

(a) Autocrine signaling

(b) Endocrine signaling

(c) Paracrine signaling

(d) Juxtacrine signaling

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