Biochem:
1
1. Identify if the following enzymes in the liver are active,inactive or unaffected during fasting
a. Branching Enzyme -
b. Debranching Enzyme -
c. Glycogen Synthase -
d. Glycogen Phosphorylase -
e. Glucokinase -
2. Explain the outcomes of each of the following GlycogenStorage Diseases
a. Lack of Debranching Enzyme -
b. Lack of Muscle Glycogen â
c. Lack of Glut-2 transporters -
d. Lack of Branching Enzyme â
e. Lack of Liver Glycogen Synthase -
f. Lack of Glucose-6-Phosphatase -
g. Lack of Liver Glycogen â
3. Explain why Branching Enzyme and Debranching Enzyme areneeded in glycogen metabolism.
4. Suppose a mutation occurs in Phosphoglucomutase which doesnot allow the enzyme to catalyze the movement of the phosphategroup from the 6 position of glucose to the 1 position. What wouldbe the effects of this mutation in Glycogen metabolism?
2
4. Suppose a mutation occurs in Phosphoglucomutase which doesnot allow the enzyme to catalyze the movement of the phosphategroup from the 6 position of glucose to the 1 position. What wouldbe the effects of this mutation in Glycogen metabolism?
5. Liver glycogen is used in fasting to provide glucose for useby other tissues including the brain. Muscle glycogen is not. Whatis the explanation for this?
2
4. Suppose a mutation occurs in Phosphoglucomutase which doesnot allow the enzyme to catalyze the movement of the phosphategroup from the 6 position of glucose to the 1 position. What wouldbe the effects of this mutation in Glycogen metabolism?
5. Liver glycogen is used in fasting to provide glucose for useby other tissues including the brain. Muscle glycogen is not. Whatis the explanation for this?
6. Which of the following statements about the control ofglycogen synthase are correct? Select all that apply.
a) Glycogen synthase is inactivated by a proteinphosphatase.
b) Glycogen synthase is activated in the presence ofinsulin.
c) PKA and glycogen synthase kinase 3 phosphorylate glycogensynthase at different sites.
d) The phosphorylation by glycogen synthase kinase 3 isinhibited by insulin.
e) Insulin activates protein kinase B which phosphorylatesglycogen synthase.
Biochem:
1
1. Identify if the following enzymes in the liver are active,inactive or unaffected during fasting
a. Branching Enzyme -
b. Debranching Enzyme -
c. Glycogen Synthase -
d. Glycogen Phosphorylase -
e. Glucokinase -
2. Explain the outcomes of each of the following GlycogenStorage Diseases
a. Lack of Debranching Enzyme -
b. Lack of Muscle Glycogen â
c. Lack of Glut-2 transporters -
d. Lack of Branching Enzyme â
e. Lack of Liver Glycogen Synthase -
f. Lack of Glucose-6-Phosphatase -
g. Lack of Liver Glycogen â
3. Explain why Branching Enzyme and Debranching Enzyme areneeded in glycogen metabolism.
4. Suppose a mutation occurs in Phosphoglucomutase which doesnot allow the enzyme to catalyze the movement of the phosphategroup from the 6 position of glucose to the 1 position. What wouldbe the effects of this mutation in Glycogen metabolism?
2
4. Suppose a mutation occurs in Phosphoglucomutase which doesnot allow the enzyme to catalyze the movement of the phosphategroup from the 6 position of glucose to the 1 position. What wouldbe the effects of this mutation in Glycogen metabolism?
5. Liver glycogen is used in fasting to provide glucose for useby other tissues including the brain. Muscle glycogen is not. Whatis the explanation for this?
2
4. Suppose a mutation occurs in Phosphoglucomutase which doesnot allow the enzyme to catalyze the movement of the phosphategroup from the 6 position of glucose to the 1 position. What wouldbe the effects of this mutation in Glycogen metabolism?
5. Liver glycogen is used in fasting to provide glucose for useby other tissues including the brain. Muscle glycogen is not. Whatis the explanation for this?
6. Which of the following statements about the control ofglycogen synthase are correct? Select all that apply.
a) Glycogen synthase is inactivated by a proteinphosphatase.
b) Glycogen synthase is activated in the presence ofinsulin.
c) PKA and glycogen synthase kinase 3 phosphorylate glycogensynthase at different sites.
d) The phosphorylation by glycogen synthase kinase 3 isinhibited by insulin.
e) Insulin activates protein kinase B which phosphorylatesglycogen synthase.
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