Question

Hematopoiesis, Stem Cells and Niches.

a.Provide a basic description of the experiments by Till and McCulloch that demonstrated the presence of stem cells in bone marrow.

b.Describe niche hypothesis and the challenges it brings to understanding adult stem cells.

c. Describe the behavior of hematopoietic stem cell and their stem cell niche. How can their behavior be used to support niche hypotheses and what challenges does their behavior bring to niche hypothesis.