Question

A protein can fold from a disordered polypeptide chain into its highly-ordered three-dimensional structure spontaneously (that is, without an input of energy). From what you have learned about thermodynamics, you can conclude that:

A.The free energy change of the protein-folding process is negative.

B.The change in enthalpy of protein folding must be sufficiently negative to overcome the local decrease in entropy when the protein folds.

C.The entropy of the environment surrounding the protein must have increased in some way in order to conform to the second law of thermodynamics.

D.All of the above.