1.Steroid hormones are known to increase theexpression of specific genes in selected target cell types.Testosterone increases the production of a protein calledalpha-2-microglobulin (?2m) in the liver and hydrocortisone (aglucocorticoid) increases the production of tyrosineaminotransferase (TAT) in the liver. (Each hormone does many otherthings). All steroid hormone receptors consists of 3 related, butdistinct, protein domains: a hormone binding domain, a DNA bindingdomain, and a regulatory domain.
A.How is it that testosterone and hydrocortisone can selectivelyinfluence the expression of two different genes in the sametissue?
B.By what you know of domains, suppose you carry out a domainswap experiment to exchange the DNA binding domains of testosteronereceptor and glucocorticoid receptor with each other. What effectswould you now expect the two hormones to have in cells containingthe altered receptors?
1.Steroid hormones are known to increase theexpression of specific genes in selected target cell types.Testosterone increases the production of a protein calledalpha-2-microglobulin (?2m) in the liver and hydrocortisone (aglucocorticoid) increases the production of tyrosineaminotransferase (TAT) in the liver. (Each hormone does many otherthings). All steroid hormone receptors consists of 3 related, butdistinct, protein domains: a hormone binding domain, a DNA bindingdomain, and a regulatory domain.
A.How is it that testosterone and hydrocortisone can selectivelyinfluence the expression of two different genes in the sametissue?
B.By what you know of domains, suppose you carry out a domainswap experiment to exchange the DNA binding domains of testosteronereceptor and glucocorticoid receptor with each other. What effectswould you now expect the two hormones to have in cells containingthe altered receptors?
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