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28 Nov 2019

Discuss the significance of the following in nucleic acid synthesis and / or degradation. a. Aspartate b. uric acid. c. carbamoyl phosphate synthetase d. xanthine

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Sixta Kovacek
Sixta KovacekLv2
18 May 2019
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Related questions

Aspartate transcarbamoylase (ATCase) catalyzes the formation ofN-carbamoyl aspartate from carbamoyl phosphate and aspartate, astep in the multienzyme process that synthesizes cytidinetriphosphate (CTP).

a.) Is ATCase an allosteric enzyme? How do you know?

b.) What kind of effector is CTP’s effect on ATCase? Explain

What is the biological significance of ATP’s effect onATCase?

c.) What kind of effector is ATP? Explain. What is thebiological significance of ATP’s effect on ATCase?

Aspartate transcarbamoylase (ATCase) catalyzes the formation ofN-carbamoyl aspartate from carbamoyl phosphate and aspartate, astep in the multienzyme process that synthesizes cytidinetriphosphate (CTP).

Carbamoyl phosphate + aspartate = N-carbamoylaspartate ===UMP== UTP=CTP

Kinetic studies of ATCaseactivity as a function of aspartate concentration yield the resultsshown in the graph.

NOTE: from graph: WITH ATP;Aspartame (nM) Has a higher % relative activity.

NO CTP OR ATP: theline is between both the above and bottom lines.

with CTP:Aspartame (nM) Has the lowest % relative activity.

a) Is ATCase an allosteric enzyme? How do you know?

b) What kind of an effector is CTP? Explain. What is the biological significance of CTP’seffect on ATCase?

c) What kind of an effort is ATP?Explain. What is the biological significance of ATP’s effect onATCase?

1. preparing a fatty acid to be catabolized through beta oxidation involves all of these except:

A. expenditure of 2 ATP equivalents.

B. attachment to carnitine.

C. crossing from the matrix into the cytosol through a translocase.

D. attachment to Coenzyme A

2. Ketone body formation

A. produces a water-insoluble fuel for brain cells.

B. occurs only under starvation conditions.

C. takes place in the cytosol.

D. allows acetyl CoA to be made into net glucose.

E. is favored when the citric acid cycle is inhibited.

3. Which statement concerning fatty acid synthesis is false?

A. Fatty acid synthesis from acetyl CoA requires ATP hydrolysis.

B. Fatty acid synthesis requires acetyl CoA to leave the matrix in the form of citrate.

C. Fatty acid synthesis takes place on a multifunctional enzyme complex.

D. Fatty acid synthesis is regulated at the carnitine transporter.

4. Cholesterol is transported from peripheral tissues to the liver as

A. chylomicrons.

B. VLDLs.

C. IDLs.

D. LDLs.

E. HDLs.

5.

The most common route for a nitrogen atom removed from a branched amino acid in muscle tissue to formation of urea is

A. branched AA --> glutamate--> glutamine --> carbamoyl phosphate --> urea

B. branched AA --> alanine--> aspartate --> glutamine --> urea

C. branched AA --> aspartate--> alanine --> glutamate --> glutamine --> urea

D. branched AA à alanineà glutamate à carbamoyl phosphate à urea

E. branched AA à glutamateà arginine à carbamoyl phosphate à urea

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